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Warfarin is a medicine that makes your blood less likely to form clots. It is important that you take warfarin exactly as you have been told. Changing how you take your warfarin, taking other medicines, and eating certain foods all can change the way warfarin works in your body. If this happens, you may be more likely to form a clot or have bleeding problems.
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Warfarin is a medicine that makes your blood less likely to form clots. This may be important if:
- You have already had blood clots in your leg, arm, heart, or brain.
- Your health care provider is worried that a blood clot may form in your body. People who have a new heart valve, a large heart, a heart rhythm that is not normal, or other heart problems may need to take warfarin.
When you are taking warfarin, you may be more likely to bleed, even from activities you have always done.
Changing how you take your warfarin, taking other medicines, and eating certain foods all can change the way warfarin works in your body. If this happens, you may be more likely to form a clot or have bleeding problems.
It is important that you take warfarin exactly as you have been told.
- Take only the dose your provider has prescribed. If you miss a dose, call your provider for advice.
- If your pills look different from your last prescription, call your provider or pharmacist right away. The tablets are different colors, depending on the dose. The dose is also marked on the pill.
Your provider will test your blood at regular visits. This is called an INR test or sometimes a PT test. The test helps make sure you are taking the right amount of warfarin to help your body.
Alcohol and some medicines can change how warfarin works in your body.
- DO NOT drink alcohol while you are taking warfarin.
- Talk with your provider before taking any other over-the-counter medicines, vitamins, supplements, cold medicines, antibiotics, or other drugs.
Tell all of your providers that you are taking warfarin. This includes doctors, nurses, and your dentist. Sometimes, you may need to stop or take less warfarin before having a procedure. Always talk to the provider who prescribed the warfarin before stopping or changing your dose.
Ask about wearing a medical alert bracelet or necklace that says you are taking warfarin. This will let providers who take care of you in an emergency know that you are taking this drug.
Some foods can change the way warfarin works in your body. Make sure you check with your provider before making any big changes in your diet.
You do not have to avoid these foods, but try to eat or drink only small amounts of them. In the least, DO NOT change much of these foods and products you eat day-to-day or week-to-week:
- Mayonnaise and some oils, such as canola, olive, and soybean oils
- Broccoli, Brussels sprouts, and raw green cabbage
- Endive, lettuce, spinach, parsley, watercress, garlic, and scallions (green onions)
- Kale, collard greens, mustard greens, and turnip greens
- Cranberry juice and green tea
- Fish oil supplements, herbs used in herbal teas
Because being on warfarin can make you bleed more than usual:
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- You should avoid activities that could cause an injury or open wound, such as contact sports.
- Use a soft toothbrush, waxed dental floss, and an electric razor. Be extra careful around sharp objects.
Prevent falls in your home by having good lighting and removing loose rugs and electric cords from pathways. DO NOT reach or climb for objects in the kitchen. Put things where you can get to them easily. Avoid walking on ice, wet floors, or other slippery or unfamiliar surfaces.
Make sure you look for unusual signs of bleeding or bruising on your body.
- Look for bleeding from the gums, blood in your urine, bloody or dark stool, nosebleeds, or vomiting blood.
- Women need to watch for extra bleeding during their period or between periods.
- Dark red or black bruises may appear. If this happens, call your doctor right away.
Call your provider if you have:
- A serious fall, or if you hit your head
- Pain, discomfort, swelling at an injection or injury site
- A lot of bruising on your skin
- A lot of bleeding (such as nosebleeds or bleeding gums)
- Bloody or dark brown urine or stool
- Headache, dizziness, or weakness
- A fever or other illness, including vomiting, diarrhea, or infection
- You become pregnant or are planning to become pregnant
Jaffer IH, Weitz JI. Anticoagulant drugs. In: Sidawy AN, Perler BA, eds. Rutherford's Vascular Surgery and Endovascular Therapy. 9th ed. Philadelphia, PA: Elsevier; 2019:chap 39.
Kager L, Evans WE. Pharmacogenomics and hematologic diseases. In: Hoffman R, Benz EJ, Silberstein LE, Heslop HE, Weitz JI, Anastasi J, eds. Hematology: Basic Principles and Practice. 6th ed. Philadelphia, PA: Elsevier Saunders; 2018:chap 8.
Schulman S, Hirsh J. Antithrombotic therapy. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 38.
Updated by: Michael A. Chen, MD, PhD, Associate Professor of Medicine, Division of Cardiology, Harborview Medical Center, University of Washington Medical School, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
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Hopefully, you just looked at the page on adding fractions. The rules for subtracting fractions are almost the same. You'll be looking for those common denominators. There is a risk with subtraction that you'll get some negative numbers, and we'll give you an example for that possibility too. Don't worry. It's just like regular subtraction.
We'll start with simple examples and give you some fractions with the same denominators (number on the bottom). Subtracting like fractions is similar to regular subtraction. You only need to focus on the numerators (numbers on top).
6/13 - 1/13 = ?
• Create common denominators: They are already the same at 13, so we do nothing.
• Subtract the second numerator from the first: 6 - 1 = 5
• Write the difference of the numerators above the common denominator: 5/13.
• Simplify the fraction if you need to. 5/13 cannot be simplified. You are done.
Answer: 6/13 - 1/13 = 5/13
7/9 - 1/9 = ?
• Create common denominators: The denominators are the same. Do nothing.
• Subtraction of numerators: 7 - 1 = 6
• Write the difference of the numerators above the common denominator: 6/9.
• Simplify: 6 and 9 have a common factor of 3. When you divide the numerator and denominator by 3 you get 2/3.
Answer: 7/9 - 1/9 = 6/9 = 2/3
Let's get more advanced. What about subtracting unlike fractions? You don't have common denominators. We've looked at creating equivalent fractions in an earlier lesson. You will use that process here.
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1/3 - 1/7 = ?• Create common denominators: We have 7 and 3. They have no common factors, so let's just multiply to create two new equivalent fractions. Remember how we multiplied by equivalents of 1? It went like this..
1/3 = 1/3 * 1 = 1/3 * 7/7 = (1*7)/(3*7) = 7/21
1/7 = 1/7 * 1 = 1/7 * 3/3 = (1*3)/(7*3) = 3/21
You now have the common denominator 21.
• Rewrite the problem as 7/21 - 3/21 = ?
• Subtract numerators: 7 - 3 = 4
• Write the difference of the numerators above the common denominator: 4/21
• Simplify: 4/21 cannot be simplified. You are done.
Answer: 1/3 - 1/7 = 4/21
Let's try one more with unlike fractions.
4/5 - 2/3 = ?
• Create common denominators: We have 5 and 3. They have no common factors, so let's just multiply by equivalents of 1 to create two new equivalent fractions:
4/5 = 4/5 * 1 = 4/5 * 3/3 = (4*3)/(5*3) = 12/15
2/3 = 2/3 * 1 = 2/3 * 5/5 = (2*5)/(3*5) = 10/15
You now have the common denominator 15.
• Rewrite the problem as 12/15 - 10/15 = ?
• Subtract numerators: 12 - 10 = 2
• Write the difference of the numerators above the common denominator: 2/15
• Simplify: 2/15 cannot be simplified. You are done.
Answer: 4/5 - 2/3 = 2/15
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You will find more problems like this in your homework. We also have a second page on subtracting fractions where we talk about negative values and mixed numbers.Right Away Fallon
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